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First published online January 14, 2005

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The ERGIC comes alive

Newly synthesized secretory proteins leave the endoplasmic reticulum (ER) in COPII-coated vesicles and pass through the tubulovesicular membrane clusters of the ER-Golgi intermediate compartment (ERGIC) to reach the Golgi. But is the ERGIC a pre-existing stationary structure (the stable compartment model), or is it formed by the fusion of COPII vesicles (the maturation model)? Hans-Peter Hauri and co-workers use live-cell imaging to provide strong evidence in favour of the stable compartment model (see p. 357). The authors compare the trafficking of GFP-labelled ERGIC-53, a membrane lectin that recycles from the ERGIC to the ER, with the movement of the anterograde marker protein VSV-G-GFP and the fluorescent protein dsRed. Their results indicate that GFP-ERGIC-53 mainly localizes to long-lived stationary elements plus some short-lived highly mobile elements, which may act as fast carriers between individual ERGIC clusters. The authors conclude that anterograde and retrograde cargos are repeatedly sorted in the ERGIC structures through a dissociative process, the molecular mechanism of which remains to be determined.

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Live imaging of bidirectional traffic from the ERGIC

Houchaima Ben-Tekaya, Kota Miura, Rainer Pepperkok, and Hans-Peter Hauri
JCS 2005 118: 357-367. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?