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Fig. 4. Transport and anchoring of oskar mRNA in Drosophila oogenesis. (1) In early oogenesis (stage 2-6), the MTs extend from the oocyte posterior to the nurse cells. Then, oskar mRNA is transported from the nurse cells, on the MTs, via ring canals, to the posterior cortex of the oocyte. (2) In mid oogenesis (stage 8), there is a re-polarization of the oocyte MTs, the MTOC at the oocyte posterior disassembles, and new MTs are nucleated from most of the oocyte cortex. The plus-end-directed motor kinesin transports oskar mRNA away from the cortex and towards the oocyte interior. (3) Subsequent destabilization of MTs at the oocyte posterior (late stage 8 and early stage 9) uncovers the posterior actin anchor, leading to the entrapment and concentration of oskar mRNA at the posterior pole [adapted from Cha et al. (Cha et al., 2004)].

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