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Fig. 8. Model of transitions of {alpha}5ß1 integrin for fibrillar-adhesion-formation and fibronectin fibrillogenesis. (a) Predicted domain structure of {alpha}5ß1 integrin. The green box (calf domains) indicates the region containing the SNAKA51 epitope. Blue circles represent cations bound to the MIDAS and ADMIDAS sites in the ß-integrin A-domain. (b) (1) Inactive integrin is diffusely located on the cell surface. (2) {alpha}5ß1 located in focal adhesions expresses epitopes reporting a primed ß1 conformation (e.g. 9EG7). These integrins may or may not be fully bound by ligand. (3) Integrin located at the distal edge of focal adhesions has additional SNAKA51 epitope expression. Clustering of this integrin promotes translocation. (4) Ligated and clustered integrin translocates out of focal adhesions along the actin cytoskeleton, stretching extracellular fibronectin fibrils and driving fibrillogenesis.





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