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Fig. 6. {Delta}POP6 and endogenous profilin localize to cytoplasmic membranes in PtK2 cells in a mitochondrial targeting assay. Cells were transiently transfected with vectors coding for a fusion protein containing a mitochondrial outer membrane fragment (MOM) and either BiPro-{Delta}POP6 or BiPro-E-cadherin (control). Staining was performed with MitoTrackerTM, a monoclonal antibody against the BiPro tag and a polyclonal anti-profilin antibody. Double-fluorescence images show that both MOM fusion proteins target to mitochondrial membranes (A,A',C,C') but only {Delta}POP6 recruits endogenous profilin to this position (B,B'), whereas E-cadherin fails to do so (D,D'). Bar, 10 µm.





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