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Fig. 1. Elastin-derived peptides enhanced in vivo and ex vivo angiogenesis. (A) Representative photomicrographs of CAM from chick embryos at day 7 (D7) and 8 (D8) of embryonic development treated daily from day 6 of embryonic development with PBS (control), 50 ng of {kappa}-elastin (KE) or 200 ng VGVAPG peptide. (B) Representative photomicrographs of capillary tube formation in three-dimensional type I collagen gel by HMECs incubated in the absence or presence of 100 ng/ml KE. (C) Representative photomicrographs of capillary-like structures from HUVECs cultured on matrigel for 14 hours in the absence (control) or presence of KE (10 and 100 ng/ml). As a positive control, VEGF (20 ng/ml)-induced tubulogenesis is shown in comparison to KE (100 ng/ml). (D) Semi-quantitative evaluation of pseudotube formation was performed by determining the number of black pixels per field. Results, each based on ten randomly selected fields, are expressed as mean±s.d. of four experiments. ***P<0.001 compared to the control level.





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