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Fig. 2. Spectrin is localized in specialized ß3-integrin clusters that mediate the initial adhesion of BAE cells but is not present in focal complexes or focal adhesions. BAE cells were allowed to spread on fibronectin-coated coverslips fixed, permeabilized, and dual-labeled with monoclonal antibody against {alpha}vß3 integrin and polyclonal antibodies against spectrin. Confocal analysis was performed on horizontal (x-y plane) optical sections (0.3 µm intervals). (A) Seven sections going from the upper to the lower surface of the cell (top panels to bottom panels) are shown. (B and C) Six sections going from the upper to the lower surface of the cell (top left to bottom right panel) are shown. Panel A shows sections through two cells 30 minutes after plating; Panel B, shows sections through a peripheral region of a cell 1 hour after plating; Panel C shows sections through a peripheral region of a cell 8 hours after plating. Bar, 5 µm.





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