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Fig. 1. Bioactive sphingolipid metabolites. The schematic depicts the sphingolipid biosynthetic pathway: LPP, lipid phosphate phosphatase; SPP-1, S1P phosphatase-1; CERK, ceramide kinase; SphK, sphingosine kinase; SM, sphingomyelin. Differential/opposing signaling roles of sphingosine, S1P, ceramide and C1P are indicated. Because of the interconvertibility of these molecules, the activity of a single enzyme in the depicted pathways may affect the fate of the cell.





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