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Fig. 2. Roles of SphK1 and CERK in eicosanoid synthesis. The roles of S1P and C1P in eicosanoid synthesis in response to inflammatory cytokines are indicated, beginning with the first step, induction of cyclooxygenase-2 (COX-2). This `primes' the cell for PGE2 synthesis and requires the generation of S1P by SphK1, followed by a receptor-mediated signaling event initiated by interaction of S1P with its receptor. The second step of prostanoid biosynthesis in response to IL-1ß, involves the activation of cPLA2 and generation of arachidonic acid (AA), which requires CERK and the generation of C1P.





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