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Fig. 3. SphK1 and CERK in mast cell functions. Crosslinking of the high affinity IgE receptor Fc{epsilon}RI on mast cells translocates and activates SphK1, increasing S1P formation. S1P in turn transactivates S1P1 and S1P2 receptors, leading to mast cell degranulation and cell motility. Furthermore, CERK may also regulate degranulation of mast cells.





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