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Fig. 2. Tau- and -synuclein-containing structures move at rates comparable with fast transport. (A,B) Rat cortical neuron transfected with 0N4Rtau-EGFP, 48 hours after transfection. The movement of tau-containing structures were monitored using live image analysis. The frames, taken at the indicated time intervals in seconds, show live images of tau-containing structures moving at a rate comparable with that of fast transport. The frames show overall anterograde (A) and retrograde (B) movement of a tau-containing structure (*). See also supplementary material Movies 1 and 2. (A',B') Tracking of the tau-containing structures shown in A and B. (C,D) As A and B, showing overall anterograde (C) and retrograde (D) movement of -synuclein-containing particles. See also supplementary material Movies 3 and 4. (C',D') Tracking of the -synuclein-containing particles shown in C and D. Bar, 10 µm.

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