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Fig. 5. GST-tau and GST-{alpha}-synuclein each interact with protein complexes containing kinesin-1, whereas only GST-{alpha}-synuclein interacts with protein complexes containing dynein. Western blots of rat brain homogenate incubated with GST, GST-tau or GST-{alpha}-synuclein bound to glutathione-Sepharose beads. Bound proteins were analysed on western blots with antibodies against kinesin-1 (A, B) or dynein (C,D). Panels A and B show an interaction of GST-tau and GST-{alpha}-synuclein with kinesin-1 in brain homogenate, respectively. There is no detectable interaction between GST-tau and dynein (C), whereas GST-{alpha}-synuclein interacts with dynein (D). No interactions were detected in brain homogenate incubated with purified GST alone.





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