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Fig. 6. p190 is required for Sema4D-induced neurite outgrowth. PC12 neuroblasts were grown for 48 hours in the presence of 50 ng/ml NGF, with or without 1 nM Sema4D, and then fixed and photographed. Scale bar: 20 µm. The bar chart shows the mean percentage of cells with neurites (extending for at least one cell diameter) counted in three separate fields. Results are representative of two independent experiments. As discussed in the text, PC12 neuroblasts displayed minimal (if any) functional response to treatment Sema4D only (not shown). However, Sema4D-dependent synergism with NGF-induced neuritogenesis is abrogated in cells depleted of p190 by targeted expression of siRNAs.





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