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Fig. 4. Activation of PLC and PI 3-kinase are involved in RA-induced facilitation of SSC frequency. The continuous traces depict the effects of RA on frequency enhancement of SSCs in the presence of, a PLC
inhibitor, U73122 (A, 5 µM), a G protein inhibitor, GDPßS (B, 5 mM), a PI3 kinase inhibitor, wortmannin (C, 100 nM) and LY294002 (D, 5 µM). Downward deflections are SSCs (Vh=–70 mV). Scale bars: 1 nA, 20 seconds.
