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Fig. 2. EM images of resting and CCH-stimulated lacrimal acini. (A) Filament distribution in resting (CON) and CCH-stimulated (5 minutes, 100 µM) lacrimal acini. (B) Filament distribution in BDM-treated (10 mM, 15 minutes) and ML-7-treated (40 µM, 15 minutes) lacrimal acini exposed to CCH (5 minutes, 100 µM). Boxed regions in the left column are magnified in the right column. L, lumen; SV, secretory vesicle; arrowheads, swaths of filaments beneath the APM or, in CCH-stimulated acini, assembled beneath multiple SVs and arrows, filaments associated with individual SVs.





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