QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

Help viewing high resolution images Return to article

Fig. 2. Nuclear density decreases with age preferentially in large fibres with high domain size. Relationship of nuclei/unit fibre length (A,C,G), SADS (B,D,H) and VDS (I,J) to fibre size in young/adult (A,B) and adult/old (C-J) animals. (A,B) Larger fibres have more nuclei/unit length and each nucleus has a larger nuclear domain than small fibres during adult life (n=253 and 75 fibres in 2-month-old and 12-month-old mice, respectively). (C,D) With ageing, nuclei/unit length decrease and SADS increases in large fibres. Small fibres show no significant change. (E) Fibre type frequency is not significantly altered in superficial TA with age. (F-J) Fibres pooled into small (<1500 µm²), medium (1500-2500 µm²) and large (>2500 µm²) groups emphasize that the fibre population becomes smaller during ageing (F). Number of fibres in small-sized (n=27, 54, 100) at 12 months, 22-24 months and 26-29 months, respectively, in medium-sized (n=37, 37, 45) and large-sized (n=37, 29, 40) fibres. Large fibres have more nuclei per unit length, but lose this advantage with age (G). This change is reflected by an increase in domain size in large fibres (H-J). *P<0.05, **P<0.01, ***P<0.001. Error bars indicate fibre to fibre s.e.m.

Return to article