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Fig. 7. Morphology of pre-melanosomes is altered upon expression of EGFP-Myo1b. (A) Ultra-thin section of Epon-embedded nontransfected MNT1 cells. Several melanosomal stages (II, III and IV) as well as coated sorting MVEs (CE) are shown. (B) Ultra-thin section of Epon-embedded EGFP-Myo1b cells. Stage-II and stage-III melanosomes show disrupted intraluminal fibrils and abnormal deposits of melanin (stars). Bars, 200 nm.





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