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Fig. 1. The dose-dependent effects of mßcd on CV-PM fusion. (A) Ca2+ activity curves (n=3) following treatments with concentrations of mßcd as indicated. (B) Kinetics of fusion of CV-PM preparations treated as in A, triggered with 189±19 µM [Ca2+]free (n=2). (C) Total cholesterol in CV-PM preparations after treatment with the indicated concentration of mßcd, expressed relative to untreated preparations. *Significant difference from control (P<0.05) and other treatments (P<0.005); **, ***significant difference from control and other treatments (P<0.001).





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