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Fig. 1. Localization and wortmannin-sensitive translocation of expressed PH-GFP chimeras that recognize PIP3 in NIH 3T3 cells. NIH 3T3 cells were transfected with the indicated PH-GFP constructs and live cells were examined by confocal microscopy after 1 day of transfection. Note the recruitment of the PH domains (except that of the 3G variant ARNO) to the plasma membrane after PDGF stimulation, and the reversal of this by the PI 3-kinase inhibitor wortmannin.





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