First published online October 27, 2005
Journal of Cell Science 118, 2104e (2005)
© The Company of Biologists Limited
Gene regulations in nuclear envelope
Interactions between chromatin and the nuclear lamina - the dense fibrillar network beneath the nuclear envelope - represent a key mechanism for control of eukaryotic gene expression. Kristen Johansen and co-workers now provide new molecular insights into such interactions by showing that the histone kinase JIL-1 interacts with the nuclear lamina protein lamin Dm0 and regulates the morphology of the nuclear lamina in Drosophila nurse cells during oogenesis (see p. 5079). JIL-1 regulates chromatin structure and is implicated in transcriptional regulation. Using a two-hybrid screen, the authors identify Drosophila lamin Dm0 as one of its interacting partners. They then pin the interaction down to the C-terminal domain of JIL-1 and the tail domain of lamin Dm0. Finally, they report that nuclear positioning and lamina morphology are abnormal in JIL-1 mutant egg chambers. The interaction between JIL-1 and lamin Dm0 may thus be important for the gene regulatory function of the nuclear lamina and critical for the gene expression programs that regulate development.

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- The JIL-1 kinase interacts with lamin Dm0 and regulates nuclear lamina morphology of Drosophila nurse cells
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JCS 2005 118: 5079-5087.
[Abstract]
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