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First published online October 27, 2005

Journal of Cell Science 118, 2104e (2005)
© The Company of Biologists Limited
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In this issue

Gene regulations in nuclear envelope


Interactions between chromatin and the nuclear lamina - the dense fibrillar network beneath the nuclear envelope - represent a key mechanism for control of eukaryotic gene expression. Kristen Johansen and co-workers now provide new molecular insights into such interactions by showing that the histone kinase JIL-1 interacts with the nuclear lamina protein lamin Dm0 and regulates the morphology of the nuclear lamina in Drosophila nurse cells during oogenesis (see p. 5079). JIL-1 regulates chromatin structure and is implicated in transcriptional regulation. Using a two-hybrid screen, the authors identify Drosophila lamin Dm0 as one of its interacting partners. They then pin the interaction down to the C-terminal domain of JIL-1 and the tail domain of lamin Dm0. Finally, they report that nuclear positioning and lamina morphology are abnormal in JIL-1 mutant egg chambers. The interaction between JIL-1 and lamin Dm0 may thus be important for the gene regulatory function of the nuclear lamina and critical for the gene expression programs that regulate development.


Related articles in JCS:

The JIL-1 kinase interacts with lamin Dm0 and regulates nuclear lamina morphology of Drosophila nurse cells
Xiaomin Bao, Weiguo Zhang, Robert Krencik, Huai Deng, Yanming Wang, Jack Girton, Jørgen Johansen, and Kristen M. Johansen
JCS 2005 118: 5079-5087. [Abstract] [Full Text]  




This Article
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