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Fig. 1. Schematic structure of CZH proteins. The CZH1 (CDM-zizimin homology 1), CZH2 (CDM-zizimin homology 2), SH3 (Src homology 3) and PH (pleckstrin homology) domains are displayed. Areas outside the CZH1 or CZH2 domains with similarity to zizimin1 or Dock180 are hatched or crossed, respectively. Sequences obtained by computational translation are marked by asterisks. The tree represents the hypothetical evolution of the proteins based on sequence similarity. Ce, Caenorhabditis elegans; Dd, Dictyostelium discoideum; Dm, Drosophila melanogaster; Hs, Homo sapiens; Neurospora c., Neurospora crassa; S. cerevisiae, Saccharomyces cerevisiae; Trypanosoma b., Trypanosoma brucei.





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