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Fig. 3. Aberrant development in Cx37-deficient ovaries is due to defects in oocytes, not granulosa cells. (A) A 37–/–oo/37+/+gc ovary containing only type 4 secondary follicles. (B) A 37+/+oo/37–/–gc ovary showing antral follicles. The graphs show mean oocyte (C) and follicle (D) diameters for chimeric ovary combinations in parallel with grafted wild-type, Cx37 and Cx43 knockout ovaries (BL/6 background). Measurements from 43+/+oo/43–/–gc ovaries on the same background are included in both C and D for comparison. Bars with different letters above them are significantly different (P<0.01). The numbers in parentheses indicate the numbers of oocytes or follicles measured. Bar, 50 µm.





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