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Fig. 6. Genetic interaction between JIL-1³⁶⁵⁷ and Lam alleles. (A) Presence of a heterozygous Lam⁴⁶⁴³ allele increases the viability of JIL-1³⁶⁵⁷ homozygous animals. Lam⁴⁶⁴³/CyO; JIL-1³⁶⁵⁷/JIL-1³⁶⁵⁷ males were mated with Sp/CyO; JIL-1³⁶⁵⁷/JIL-1³⁶⁵⁷ females. Homozygous JIL-1³⁶⁵⁷ individuals that were also homozygous for the wild-type Lam allele (histogram to the right) eclosed at a rate only about half (0.44) that of JIL-1³⁶⁵⁷ homozygotes that contained one copy of the loss-of-function Lam⁴⁶⁴³ allele (histogram to the left). The average ratios of adult flies of each genotype to total eclosed flies are from 13 independent matings. The difference in numbers observed for the two classes was statistically significant (P<0.0001, Student's two-tailed t-test). (B) The presence of a heterozygous Lam^A25 allele does not affect the viability of JIL-1³⁶⁵⁷ homozygous animals. Lam^A25/CyO; JIL-1³⁶⁵⁷/JIL-1³⁶⁵⁷ males were mated with Sp/CyO; JIL-1³⁶⁵⁷/JIL-1³⁶⁵⁷ females. Homozygous JIL-1³⁶⁵⁷ individuals that were also homozygous for the wild-type Lam allele (histogram to the right) eclosed at the same rate (0.97) as JIL-1³⁶⁵⁷ homozygotes that contained one copy of the Lam^A25 allele (histogram to the left). The average ratios of adult flies of each genotype to total eclosed flies are from 21 independent matings. The difference in numbers observed for the two classes was not statistically significant (P>0.8, Student's two-tailed t-test).

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