spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 10. Interaction of FGF2 and CNP signaling in RCS cells. FGF2 inhibits proliferation and triggers matrix degradation in RCS cells through activation of the Erk MAP kinase pathway. CNP signaling counteracts FGF2 effects by inhibiting the Erk pathway at the level of Raf-1. In addition, CNP directly stimulates RCS matrix production thereby further compensating for the FGF2-mediated matrix loss. The inhibitory effect of FGF2 on RCS matrix production is not presently clear (dashed line).





Right arrow Return to article