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Fig. 4. CNP inhibits FGF2-mediated Erk MAP kinase activation via PKG. (A) Serum-starved cells were pre-treated with the PKG inhibitor KT5823 for 30 minutes before treatment with FGF2 and CNP (30 minutes) and analyzed for Erk phosphorylation by WB. Levels of total Erk2 serve as a loading control. (B) Cells were treated with FGF2 and cGMP analogs that either activate PKG (pCPT-cGMP) or inhibit PKG (Rp-8-pCPT-cGMPS; Rp-8-Br-PET-cGMPS) for 72 hours and counted. The data represent the average from four wells with the indicated standard deviation.





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