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Fig. 2. Phylogenetic tree of model organisms indicating the number of Neks and the presence or absence of ciliated cells. NIMA kinase homologs were identified using genome-wide BLAST searches with the Aspergillus NIMA protein sequence. Candidate genes were used in reciprocal BLAST searches against the NCBI protein database (http://www.ncbi.nlm.nih.gov/BLAST/) to identify true Nek homologs. The data were codified as follows: `1' was assigned to organisms that possess ciliated cells that re-enter the cell cycle, and `0' was assigned to organisms that do not have ciliated cells that undergo cell division (numbers presented in brackets). The tree is adapted and modified from (Hedges, 2002; Pazour, 2004, Pazour, 2004).





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