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Fig. 4. Shrm-induced changes in morphology are associated with alterations in the organization of the apical actin cytoskeleton. (A-C) Control (A), induced ShrmL (B), or induced Endo-ShrmC (C) cells were grown on filters and stained to detect F-actin (A-C, A'-C') and ZO-1 (A''-C''). Boxed regions in A-C are enlarged in A'-C' and A''-C''. Inset in (C) shows Endo-ShrmC expression. Arrowhead denotes actin rings and arrows denote apical actin fibers. Images are projections of 0.2 µm sections spanning the AJC and apical plasma membrane. In all panels, scale bar represents 15 µm.





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