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Fig. 1. Concentration-dependent effects of IFN ${gamma}$ on PEG oligomer permeability and TER in T84 monolayers. After a 48-hour incubation with IFN ${gamma}$ , monolayers were mounted in modified Ussing chambers in HBSS. (A) Decrease in TER in response to basolateral IFN ${gamma}$ at concentrations of 0.01-10 ng/ml for 48 hours. (B) Apical to basolateral permeability profiles of PEG oligomers of increasing molecular mass (0.238-1.25 kDa) and molecular radius (3.5-7.4 Å) following a 48-hour incubation with 10 ng/ml ( ${blacksquare}$ ); 1 ng/ml ( ${bullet}$ ) and 0.1 ng/ml ( ${blacktriangleup}$ ) IFN ${gamma}$ or vehicle ( ${square}$ ). Permeability data is the mean of six 30-minute flux periods. Data shown are expressed as mean±s.e.m. of four monolayers in each group.

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