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Fig. 4. Dose response of the putative oocyte-secreted factors; GDF-9, BMP-6, BMP-15 on cumulus cell apoptosis. OOX were cultured with increasing concentrations of GDF-9 (0-175 ng/ml), BMP-6 (0-100 ng/ml), and BMP-15 (0-20% v/v), either in the absence (A,C,E) or presence (B,D,F) of FSH. Cumulus cell apoptosis was unaffected by GDF-9 and attenuated in a dose-dependent manner by BMP-6, but more notably by BMP-15. FSH independently attenuated apoptosis regardless of treatment or complex type. Points represent average percentage of apoptotic cumulus cells (mean ±s.e.m.). Values from points with different labels; a,b,cdiffer significantly (A,B; P<0.001). Asterisks represent significant difference (P<0.001) relative to the control (OOX) for that factor (C-F).





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