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Fig. 2. Correlation between Dvl2 puncta formation and signalling activity. COS-7 cells expressing (A) wild-type, (B) M68/69 or (C) {Delta}DIX mutant HA-Dvl2, were fixed and stained as in Fig. 1. Notice that neither mutant is able to form puncta (see also Capelluto et al., 2002). (D) Wnt signalling activity of wild-type and M68/69 mutant HA-Dvl2 in transfected 293T cells, as measured by TOPFLASH transcription assays (see Materials and Methods). Numbers underneath bars represent µg of DNA used for transfection (1, 1 and 3 µg). Protein expression levels were confirmed by western blotting (not shown). Bar, 15 µm.





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