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Fig. 7. LRP6 exhibits a limited level of Mesd degradation. (A) LRP6-mediated 125I-Mesd (5 nM) degradation in LRP6-transduced HT1080 cells and control cells was carried out for 4 hours at 37°C in the absence or presence of 500 nM Mesd. (B) 125I-Mesd (5 nM) binding to LRP6-transduced HT1080 cells and the control cells was carried out for 4 hours at 4°C in the absence or presence of 500 nM Mesd. Values are the means of triple determinations with the s.d. indicated by error bars.





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