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Fig. 3. Effects of the mTOR inhibitors RAD001 and LY294002 on IP3-evoked Ca2+ increases in voltage-clamped single colonic myocytes. The mTOR inhibitors each inhibited IP3-evoked Ca2+ increases. Photolysed caged IP3 (
) increased [Ca2+]c as indicated by F/F0. The IP3-evoked [Ca2+]c transient was significantly decreased by each inhibitor. (A) RAD001, 10 µM, n=8, P<0.05. (B) LY294002, 20 µM, n=8, P<0.05).
