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Fig. 5. Effects of the calcineurin inhibitors cypermethrin and okadaic acid on IP3-evoked Ca2+ increases in voltage-clamped single colonic myocytes. Photolysed caged IP3 ({uparrow}) increased [Ca2+]c as indicated by F/F0. The IP3-evoked [Ca2+]c transient was significantly increased by each inhibitor. (A) Cypermethrin 10 µM, n=12, P<0.001; (B) okadaic acid 5 µM, n=8, P<0.05.





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