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Fig. 6. Effect of FK506 on IP3-evoked Ca2+ increases following calcineurin inhibition in voltage-clamped single colonic myocytes. Following pre-treatment with the calcineurin inhibitors (A) CiP (100 µM), (B) okadaic acid (5 µM) or (C) cypermethrin (10 µM), FK506 (10 µM) did not increase the IP3-evoked [Ca2+]c transient produced by photolysed caged IP3 ({uparrow}) as it had done in the absence of inhibitors (cf. Fig. 4).





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