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Fig. 4. Rac-Pak pull-down assay showing the effect of CYP 2C9 and 11,12-EET on Rac activity in human endothelial cells. The amount of PAK-1-bound active Rac was determined by western blotting and compared with the amount of total Rac determined in the whole cell lysates. (A) Effect of CYP 2C9 and sulfaphenazole (Sulfa, 30 µmol/l) on Rac activity 24 hours after infection. (B) Representative western blot and bar graph showing the effect of 11,12-EET (1 µmol/l, 30 minutes) and VEGF (30 ng/ml, 30 minutes) on Rac activity. The bar graphs summarize the results of three to five independent experiments (mean±s.e.m.); *P<0.05 vs the level in the control (CTL).





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