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Fig. 4. Effect of GFX on CysLT₁ receptor activation after PMA challenge, and effect of H89 on ATP- and UDP-induced CysLT₁ desensitization. (A) Representative trace of the effect of increasing concentrations of GFX pretreatment (5 minutes) on the [Ca²⁺]_i transient induced by 10 nM LTD₄ (2nd challenge) after an initial challenge with 500 nM PMA (5 minutes). (B) Values shown represent means of [Ca²⁺]_i stimulation over basal (s/b) ± s.e.m. of at least five independent experiments. (C) Effect of 10 µM H89 pretreatment (5 minutes) on the [Ca²⁺]_i transient induced by 10 nM LTD₄ (2nd challenge) after an initial challenge with 10 nM LTD₄, 10 µM ATP or 100 µM UDP.

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