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Fig. 6. AQP4 immunostaining of astroglia in vivo. (A) Control (uninjured) wild-type (+/+) mouse brain parenchyma, showing AQP4 expression in pericapillary astroglial foot processes. (B) Stab-injured wild-type mouse brain showing strong AQP4 immunoreactivity in the astroglial scar. (C) Absence of AQP4 expression in stab-injured AQP4-null (–/–) mouse brain. The blue line demarcates the edge of the glial scar; red lines indicate the margin of injured brain. Each micrograph is representative of three mice. Bar, 100 µm.





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