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Fig. 2. APC is enriched at the axon tip prior to significant length increase. (A) Hippocampal neurons immunostained for APC and dephospho-tau were classified by two neuronal polarization criteria: length + indicates that the length of the longest neurite is greater than or equal to twice the length of the next-longest neurite; tau + indicates increased dephospho-tau staining (represented by green) in one of the neurites. Polarizing neurons were defined as dephosphotau +, length – neurons (see Results). (B) Unpolarized, polarizing and polarized neurons (left, middle and right bars, respectively) were further classified by which neurite tips had enriched APC. Black, longest extension only or most intensely; gray, two or more neurites evenly; white, no neurites or only one neurite other than the longest. Shown is the mean±s.e.m. of three independent experiments; n, total number of cells in each category.
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