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Fig. 7. Effect of postembryonic RNAi on locomotion. (A) N2 L4 larvae on negative-control plates. (B) N2 L4 larvae on elt-1 RNAi plates. The increased amplitude of the sinusoidal waveform can be seen by the exaggeratedly `looped' tracks on the bacterial lawn (arrows). (C) Mean values (±s.d.) of the number of head deflections per minute for L4 larvae on elt-1 RNAi and negative-control plates (n=10). Data is shown for the wild type (N2) and RNAi-hypersensitive rrf-3(pk1426) mutants (NL). The differences between the RNAi and control groups were statistically significant by a nonpaired t-test; P=0.0005 for N2 and P=0.0001 for rrf-3(pk1426) mutants. (D) Percentage of worms moving before and after heat-shock-induced ectopic expression of elt-1 or elt-3. JM53 and JM55 carry independent chromosomally integrated transgenes for ectopic expression of elt-1. JM59 and JM60 carry independent chromosomally integrated transgenes for ectopic expression of elt-3. The results show the mean values (±s.d.) for four independent experiments in which 100 worms were counted per group. An adult C. elegans hermaphrodite is approximately 1 mm in length.





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