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Fig. 7. Model for transcriptional control of cell separation. In separate waves of transcription, Sep1p and Ace2p promote expression of genes critical for cell separation. Ace2p controls expression of four sets of genes. The first group includes genes encoding the glucanases Agn1p and Eng1p; the second group, consisting of cfh4+, adg1+, adg2+ and adg3+, encodes proteins with as-yet-unknown function. Thirdly, Ace2p controls the expression of mid2+, whose protein product is responsible for proper septin ring organization, an event necessary for proper cell separation.





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