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Fig. 7. Summary of events believed to lead to the downregulation of desmosomal adhesion in wounded epidermis. (A) In normal epidermis PKC{alpha} is diffusely distributed in keratinocyte cytoplasm, and desmosomes have an organised structure and are Ca2+ independent. (B) Following wounding PKC{alpha} associates with the desmosomal plaque. (C,D) PKC{alpha} mediates phosphorylation of desmosomal plaque component(s). (E) A transmembrane signal generates a less-organised arrangement of the desmosomal cadherins and onset of Ca2+ dependence. (F) Whole desmosomes are internalised by wound-edge cells probably initially in association with membrane vesicles (red arrow).





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