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Fig. 2. Reduced RNA translocation in TLS-null neuronal dendrites. (A) EtBr staining of RNA-containing particles in neuronal dendrites of wild-type (+/+) and TLS-null (–/–) neurons. RNA staining of dendrites extending 20 µm from the cell body is shown. Bar, 10 µm. (B) Quantitative data on RNA staining. DHPG treatment increases the RNA content in wild-type neurons (45.1±2.8% increase, P<0.01). In TLS-null neurons, no significant increase is observed after DHPG treatment (12.6±4.1% increase, P=0.299). Without DHPG stimulation, there was no significant difference in the RNA content between wild-type and TLS-null neurons (P=0.59). *P<0.01. (C) TLS overexpression does not change the amount of RNA in either wild-type or TLS-null neurons (P=0.059 and P=0.039, +/+ and –/–, respectively). DHPG treatment significantly upregulates the RNA content in both types of neurons (*P<0.01). Representative RNA staining is shown in A (right panels). Error bars indicate s.e.m.

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