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Fig. 7. Chromosome segregation is impaired in the rqh1 mutants as a result of a defect in the resolution of rDNA repeats, which activates the spindle checkpoint. Inactivation of the spindle checkpoint by deletion of mad2 suppresses the lagging chromosome behaviour but not the aberrant structure in rDNA repeats that leads to the reduction of chromosome III length in rqh1{Delta} and rqh1{Delta} mad2{Delta} mutants.





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