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Fig. 5. The N-terminus of LEM2 is essential and sufficient for lamin A-mediated nuclear targeting. Confocal immunofluorescence images of HeLa cells or Lmna–/– MEFs transiently expressing different V5-tagged truncation mutants of hLEM2, as indicated in the schematic drawing below each image. The LEM domain is shown in red, transmembrane domains in blue, and MSC domain in green. Numbers depict aa that border each deletion. LEM2 polypeptides were detected by immunofluorescence using anti-V5 antibody (red). DNA was stained with Hoechst (blue). Arrows in the lower right image mark cytoplasmic staining of LEM2-NT in Lmna–/– MEFs. Bars, 10 µm.





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