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Fig. 1. ALK-FH-derived proteins and the inducible dimerization system. (A) Schematic representation of the induced dimerization of ALK-FH protein by the synthetic lipophylic and bifunctional dimerizer AP20187. (B) Schematic representation of the full-length ALK-FH protein and its intracellular domain as membrane-bound (transmembrane, tmbIA-FH; or myristoylated, myrIA-FH) or cytosolic (cytoIA-FH) proteins. ECD, extracellular domain; TM, transmembrane domain; PTK, protein tyrosine kinase domain; 2x FKBPv, tandem copies of modified form of the intracellular FK506-binding protein; HA, hemagglutinin tag; myr, myristoylation sequence from Src.





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