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Fig. 1. TSA-induced increase in chromatin accessibility. Examples of confocal sections of HeLa interphase cell nuclei (A-E) microinjected with 42, 77, 282, 464 and 2500 kDa and of mitotic cells microinjected with 464 kDa FITC-dextrans (F) are presented. The dextran signal is in green and the DNA counterstained with DAPI is in red. The left side shows control cells and the right side cells after 17 hours of TSA treatment. The dashed lines indicate the direction of the corresponding linescans that are shown next to the images. Scale bars, 10 µm.





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