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Fig. 4. Illustration of chromatin accessibility. The chromatin is shown in gray and macromolecules are represented by three differently sized spheres in green corresponding to the distribution of 42, 77 and 464 kDa dextrans. The left side illustrates an untreated cell, where small molecules can diffuse in all parts of the chromatin with a subfraction of heterochromatin being accessible only to the smallest particles. The large complexes are excluded from heterochromatin and restricted to more open chromatin regions in the nuclear center. The right side shows schematically the macromolecule distribution in a TSA-treated cell. The dense chromatin regions are disintegrated so that also the large complexes can distribute throughout the complete nucleus.





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