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Fig. 1. Coordinated control of SPB function and cortical capture of astral MTs establishes spindle polarity. MT capture at the prebud primes spindle polarity by directing the old SPB (dark blue) towards the new budding site. Because the SPB is embedded in the nuclear envelope, SPB movement is coupled to the migration of the nucleus towards the bud neck. After SPB duplication, MT organization by the new SPB (light blue) is delayed by Cdk. During SPB separation, a new area of cortical capture at the bud neck stops newly formed MTs from entering the bud. As a result, the new SPB is confined to the mother cell. Already at this stage, the fate of each pole (daughter-bound versus mother-bound) is clearly specified. Correct polarity brings about the orientation of the pre-anaphase spindle along the mother-bud axis. During spindle elongation, the old SPB enters the bud.





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