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Fig. 2. (A) Following an apoptotic insult, BH3-only proteins are activated, at the transcriptional and/or the post-translational level, and neutralize their pro-survival counterparts. Activation of multidomain pro-apoptotic members of the Bcl-2 family proceeds through a largely unknown mechanism, although some BH3-only factors have been proposed to participate in the process. (B) Under resting conditions, pro-survival Bcl-2 family members sequester low levels of BH3-only proteins and prevent the full activation of multidomain Bax-like factors that would have undergone conformational rearrangements resulting in the exposure of their N-terminal domains.
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