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Fig. 8. Schematic model for convergence of PS-dependent receptors {alpha}vß5 integrin and Mer signaling. We propose that Mer activates a Src family kinase, resulting in FAKTyr861 phosphorylation and subsequent recruitment of FAK to the cytoplasmic tail of ß5, thereby {alpha}vß5 integrin and Mer functionally cross-talk to amplify internalization signals.





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