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Fig. 7. Src-kinase activity is necessary for fibronectin-induced PLC-{gamma}1 phosphorylation. Null+ cells were allowed to adhere to fibronectin-coated dishes (10 µg ml-1) in serum-free medium containing 50 µM sodium pervanadate and in the presence of (A) EGF-receptor tyrosine-kinase inhibitor AG1478 or (B) Src-kinase inhibitor PP2. Then, the cells were lysed and each lysate was precipitated with anti-PLC-{gamma}1 antibodies followed by blotting with antibodies against tyrosine-783-phosphorylated PLC-{gamma}1 or PLC-{gamma}1 as indicated. In each experiment, 25 ng ml-1 EGF was added for comparative purposes.





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